Positive psychology represents a fast-growing research and practice enterprise that focuses on positive functioning, well-being, and adaptation in adversity. In contrast to a disease- or deficit-based model, positive psychology answers how people thrive despite their ill-health. Hence, the enterprise has huge implications on how we make sense of the illness experience of the patients as well as the caregiving journey of their loved ones, and is closely in line with traditional Chinese concepts about health and well-being. In this talk, I will discuss how positive psychological concepts, including gratitude, meaning, and growth, have been applied in local community health contexts to understand and foster the quality of life of patients and their families. Examples from my research and intervention works with local cancer families, infertile couples and my recent COVID-19 adjustment projects will be referenced.